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Nanoparticle-based method shows promise in DNA vaccine delivery

The research team, led by Hadi Shafiee, PhD, assistant professor at Brigham and Women’s Hospital and Harvard Medical School, together with Mohamed Shehata Draz, PhD, evaluated the technique’s ability to deliver a DNA vaccine — specifically, one against the hepatitis C virus (HCV) — into mice. They found that it induced a strong immune response, reflected by high levels of anti-HCV antibodies and immune cells that secrete specific inflammatory hormones. Importantly, no signs of toxicity was seen in the mice throughout the study period, which lasted nearly 3 months.

The study was published in Advanced Functional Materials.

The article was covered my news outlets such as Phys.org, EurekAlert and nanowerk among others . View more.

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